Immunobiology of Bacterial CpG-DNA
A. M. Krieg, G. Hartmann, A.-K. Yi (auth.), Professor Dr. Hermann Wagner Ph.D. (eds.)Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Categories:
Year:
2000
Edition:
1
Publisher:
Springer-Verlag Berlin Heidelberg
Language:
english
Pages:
246
ISBN 10:
364264077X
ISBN 13:
9783642640773
Series:
Current Topics in Microbiology and Immunology 247
File:
PDF, 7.00 MB
IPFS:
,
english, 2000
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